The risk of cardiovascular events in patients with subclinical hypothyroidism: An updated meta-analysis based on 53813 participants
ZHAO Ting
WEI Xiao-liang
LIU Mao
LIN Xiu-fang
摘要：Background Subclinical hypothyroidism is a metabolism disease with elevated thyroid stimulating hormone (TSH) and normal thyroid hormone levels.Patients with subclinical hypothyroidism can have abnormal lipid metabolism,hypertension,coagulation dysfunction,vascular endothelial dysfunction.However,the relationship between subclinical hypothyroidism and cardiovascular events is still uncertain.Methods Prospective studies on the association between subclinical hypothyroidism and coronary heart disease were searched in PubMed,Embase,Wanfang databases and the Cochrane Library.The incidences of coronary heart disease,cardiac death,heart failure and all-cause death were compared between subclinical hypothyroidism group and euthyroidism group.Odds ratios (ORs) with 95％ confidence intervals (95％ CIs) were used as summary statistics.Results Thirteen eligible studies incorporating 53813 participants were included in this meta-analysis.No significant differences were found in the comparison of the risk of CHD (9.67％ vs.7.74％,OR=1.09,P=0.19),cardiac death (7.80％ vs.4.74％,OR=1.34,P=0.06),all-cause death (13.26％ vs.13.63％,OR=1.05,P=0.77) and heart failure (7.12％ vs.4.29％,OR=1.24,P=0.22) between the subclinical hypothyroidism group and euthyroidism group.Conclusions Our results indicate that subclinical hypothyroidism might not increase the risk of cardiovascular disease.
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论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 21-31 )
英文信息