Protective effects of Taxifolin on H2O2-nduced damage in H9C2 cells
HUANG Jun-gang
ZHAO Ming-yi
WANG Xiao-li
SU Qi-li
CAI Qian
LI Peng
ZHU Ping
摘要：Background Taxifolin (Tax) is an essential natural antioxidant.Multiple studies have shown that Tax can protect cardiomyocytes from ischemia-reperfusion injury.However,the underlying mechanism is still unclear.Methods H9C2 cells were randomly divided into control,H2O2 group,Tax pretreatment group (Tax + H2O2);Tax effect group.Cell activity was detected by CCK-8 and the intracellular structure was observed by transmission electron microscopy.Autophagy was determine by Western blotting analysis of Beclin-1,Bcl-2 and PKC.Results Tax pretreatment significantly increased anti-apoptotic protein Bcl-2 and autophagy protein Beclin-1.Expression of PKC was inhibited by Tax.Conclusions Tax pretreatment could protect H9C2 cells against H2O2-induced damage through the Bcl-2 and autophagy pathways.
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论文发表日期：2017-07-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 209-214 )
英文信息