N-terminal pro-B-type natriuretic peptide levels after hospital discharge in patients with acute myocardial infarction for predicting long term outcome
ZHENG Bao-juan
CHEN Jian-jia
MA dun-liang
ZHUO Sheng-qing
TIAN Xiang-ting
摘要：N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) is associated with worse outcome in patients with acute myocardial infarction (AMI).However,the role of short-term follow-up of NT-pro-BNP level remains unclear.Methods Three hundred and sixty-two patients diagnosed with AMI were retrospectively enrolled in this study from March 2014 to March 2017 in our center.Blood samples were obtained at initial admission and again within 1 month after hospital discharge.The univariate and multivariate cox regression analyses including significant covariables were performed on NT-pro-BNP level at admission,discharge,or change from admission to discharge to predict adverse cardiovascular events (MACE) as study endpoints.Results There were 211 cases in NT-pro-BNP decrease group,while 151 cases in NT-pro-BNP increase group.The median follow-up was 365 days (interquartile range [IQR],322-861 days).After adjusting the covariables in the multiple logistic regression analysis,follow-up NT-pro-BNP level was still a significant independent predictor for MACE (OR,1.395;95％ CI,1.102-1.869,P=0.005).However,the initial NT-pro-BNP level or change of NT-pro-BNP level had no significant predictive value for MACE.Conclusions A short-term follow-up NT-pro-BNP level after hospital discharge is a powerful prognostic biomarker for MACE in patients with AMI.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 168-173 )
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