Interventional closure operation increases angiotensin-(1-7) level in pulmonary arterial hypertension due to congenital heart disease
DAI Hai-long
YANG Qiang-feng
GUANG Xue-feng
YIN Xiao-long
1.Key Laboratory of Cardiovascular Disease of Yunnan Province, Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming 650051, China2.Key Laboratory of Cardiovascular Disease of Yunnan Province, Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming 650051, China3.Key Laboratory of Cardiovascular Disease of Yunnan Province, Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming 650051, China4.Key Laboratory of Cardiovascular Disease of Yunnan Province, Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming 650051, China
摘要：Background Recent studies have demonstrated that angiotensin (Ang)-(1-7) plays an important role in the development of pulmonary arterial hypertension (PAH).Our previously study showed that serum Ang-(1-7) level was decreased in patients with PAH due to congenital heart disease (CHD).The present study aimed to investigate the changes of serum Ang-(1-7) before and after intervention closure.Methods fifty-nine patients with CHD were included.The patients were divided into non-PAH (group A),mild PAH (group B) and moderate PAH (group C).The serum Ang-(1-7) was detected by enzyme-linked immunosorbent assay (ELISA) at 1 day before operation and 2 days after operation.Results Before intervention closure,serum angiotensin-(1-7) level was significantly lower in group C than that in group A and group B.After intervention closure operation,serum Ang-(1-7) level was increased in group B and group C.Conclusion Serum Ang-(1-7) level is increased in PAH patients after interventional closure operation of CHD,which might be used as potential clinical biomarkers to evaluate the postoperative prognosis for these patients.
机标关键词：
论文发表日期：2019-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 264-268 )
英文信息