A comparison between two definitions of contrast-induced acute kidney injury for risk of mortality in patients with anemia:A large cohort retrospective study with 5,406 patients
YING Ming1
LU Hong-yu1
WANG Bo1
LUN Zhu-bin2
WEI Shui-sheng3
LIU Yong1
CHEN Zhu-jun3
1.Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China;Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China2.Department of Cardiology,Dongguan Traditional Chinese Medicine Hospital,Dongguan 523127,China3.Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China
摘要：Background The relationship between contrast-induced acute kidney injury (CI-AKI) and long-term mortali-ty of anemia patients still remain controversial.Previous researches indicated that inconsistent definition may con-tributed to this problem.Methods This study conducted a retrospective cohort study enrolling 5,406 patients with anemia undergoing coronary angiography or percutaneous coronary intervention between January 2007 and December 2018 in Guangdong Provincial People's Hospital.The CI-AKI was evaluated according to two defini-tions:1.CI-AKIA:With a serum creatinine (SCr) elevation of 25％ or 0.5 mg/dL from baseline in the first 72 hours after procedure;2:CI-AKIB:With a SCr elevation of 50％ or 0.3 mg/dL from baseline in the first 72 hours after procedure.The endpoint was all-cause mortality.Univariable and multivariable Cox regression model were used to explore association between long-term all-cause mortality and CI-AKI.Population attributable risks(PARs) based on two different CI-AKI definitions for mortality were calculated.Results CI-AKIA was associat-ed with 1.36 fold risk of long-term death (HR:1.36,95％ CI:1.18-1.57),while CI-AKIB was associated with 1.32 fold risk of long-term death (HR:1.32,95％ CI:1.13-1.54).Between two definitions,the prevalence of CI-AKI was higher for CI-AKIA (16.7％),compared with CI-AKIB (12.6％).For the PARs,PAR based on CI-AKIA (PAR:5.65,95％ CI:2.91-8.67),was higher than that based on CI-AKIB (PAR:3.87,95％ CI:1.61-6.36).Conclusions Patients complicated with CI-AKI had a higher risk of mortality than those without CI-AKI in all definitions.The prevalence and PAR of CI-AKI were higher when it was defined as CI-AKIA.CI-AKIA was considered as a better definition to identify anemia patients with higher risk of CI-AKI and higher risk of CI-AKI-associated mortality.
机标关键词：
论文发表日期：2021-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 215-222,238 )
英文信息