Applicability and prognostic effect of Sequential Organ Failure Assessment score in adults hospitalized for infective endocarditis
CHEN Wei-tao1
WEI Xue-biao2
YU Dan-qing3
1.Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guang-zhou 510180,China2.Division of Geriatric Intensive Medicine,Guangdong Provincial Geriatrics Institute,Guangdong Provincial Peo-ple's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510180,China3.Division of Cardiology,Guangdong Provincial Peo-ple's Hospital,Guangdong Academy of Medical Sciences,Guangdong Cardiovascular Institute,Guangzhou 510180,China
摘要：Background Early identification of patients at risk for adverse outcomes is imperative to improve the progno-sis of infective endocarditis (IE).Sequential Organ Failure Assessment (SOFA) score has been reported as an ef-fective assessment tool for predicting the adverse outcomes of infectious diseases,but its applicability and predic-tive value in IE patients was still poorly known.Methods From 2009 to 2020,a total of 1354 patients diag-nosed with definite IE according to the modified Duke criteria were included.SOFA score was calculated by the laboratory and clinical parameters within 24 hours of diagnosis.Discrimination and calibration of SOFA for in-hospital mortality were analyzed.Results Patients were divided into two groups according to the optimal cut-off value of SOFA score =2 in the present cohort,which were determined by the receiver operating characteristic(ROC) analysis:High SOFA (≥2,n=496) group and low SOFA group (＜2,n=858).SOFA score showed good discrimination and calibration for in-hospital mortality[area under the curve (AUC):0.750,P＜0.001;Hosmer-Lemeshow P=0.210].ROC curve showed that SOFA ≥2 had a sensitivity of 73.2％ and specificity of 66.2％ for predicting in-hospital death.Kaplan-Meier analysis showed that SOFA score ≥2 was associated with higher 6-month mortality (Log-rank:96.3,P＜0.001).Conclusions SOFA score is a practical risk assessment tool for pa-tients admitted to hospital for IE and SOFA scores ≥2 is independently associated with in-hospital mortality.
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论文发表日期：2021-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 231-238 )
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