An overview of recent progress for Hutchinson-Gilford progeria syndrome
WEI Yuan-xin1
YAN Lei1
LIU Nan-bo2
ZHU Shuo-ji2
ZHU Ping2
ZHANG Hui1
1.School of Life Science and Technology,Shanghai-Tech University,Shanghai 201210,China2.Guangdong Car-diovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guang-dong 510100,China;Guangdong Provincial Key Laboratory of Pathogenesis,Targeted Prevention and Treatment of Heart Disease
摘要：Background Hutchinson-Gilford progeria syndrome(HGPS)is a rare disorder characterized by premature ag-ing and death mainly because of myocardial infarction,stroke,or heart failure.Patients with HGPS are healthy at birth,then get growth impairment,such as loss of subcutaneous fat,alopecia,osteoporosis and heart diseases in 1-2 years.HGPS is caused by progerin,which is a toxic form of lamin A expressed in most differentiated cells.Here,we discuss current views about the molecular mechanisms,the mouse models and the treatment approaches of HGPS.We summarize the work in this area and provide directions and clues for future studies.
机标关键词：hutchinsonoverviewgilfordprogeriaprogressrecentsyndrome
论文发表日期：2022-09-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 229-235 )
英文信息