The impact of perioperative sufentanil administration on cardiovascular outcomes in non-small cell lung cancer patients treated with immune checkpoint inhibitors
MAO Song-song
CHEN Jie-yuan
MA Jue
ZHANG Guang-yan
HOU Xing-hua
NONG Li-dan
CUI Jian-xiu
Department of Anesthesiology,Guangdong Provincial Peo-ple's Hospital,Guangdong Academy of Medical Sciences,Guang-zhou 510080,China
摘要：Background Non-small cell lung cancer(NSCLC)patients treated with immune checkpoint inhibitors(ICIs)are at an increased risk of cardiovascular adverse events during surgery.This study investigated the impact of peri-operative sufentanil administration on reducing these risks.Methods From July 2021 to July 2022,this observa-tional study included 139 NSCLC patients at our institution,split into an experimental group(n=88)receiving suf-entanil during surgery and a control group(n=51)who did not.The study focused on evaluating major adverse car-diovascular events(MACEs),arrhythmias,elevated troponin I,and B-type natriuretic peptide(BNP)levels as pri-mary endpoints.Results The experimental group experienced a lower incidence of arrhythmias at 9.1％com-pared to 19.6％in the control group(P=0.045),indicating a significant protective effect of sufentanil.No significant differences were found in MACEs rates(8.0％in the experimental group vs.11.8％in the control group,P=0.710),elevated troponin I(12.5％vs.19.6％,P=0.147),or BNP levels(26.1％vs.31.4％,P=0.875).Patients with existing cardiovascular risk factors demonstrated a higher overall incidence of cardiovascular adverse events,underscoring the compounded risk that these factors posed.Conclusions Perioperative administration of sufentanil in NSCLC patients undergoing surgery post-ICI therapy shows a significant reduction in the incidence of arrhythmias,suggest-ing a protective cardiovascular effect.This finding highlighted the importance of sufentanil in managing the periop-erative cardiovascular risk of these patients.[S Chin J Cardiol2024;25(1):21-28]
机标关键词：administrationcheckpointinhibitorscancerimpactcellwithcardiovascular
论文发表日期：2024-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 21-28 )
英文信息