西格列汀二甲双胍联合硝苯地平治疗高血压合并T2DM的疗效观察

YANG Li-fei

doi:10.3969/j.issn.1009-8933.2025.04.008

摘要：Background The co-existence of Type 2 diabetes mellitus(T2DM)and hypertension presents a significant clinical challenge due to their synergistic detrimental effects on cardiovascular outcomes.Conventional combina-tion therapies often fall short in comprehensively addressing the intertwined pathophysiologies,particularly vascu-lar endothelial dysfunction.This study aimed to evaluate the efficacy of a novel regimen combining sitagliptin-met-formin with nifedipine in managing blood pressure,blood glucose,and vascular function in this high-risk popula-tion.Methods 150 patients with T2DM and hypertension were randomly assigned to either the control group(n=75)treated with metformin and nifedipine,or the experimental group(n=75)treated with sitagliptin-metformin compound preparation combined with nifedipine.Changes in blood pressure,blood glucose levels,flow-mediated dilation(FMD)and nitroglycerin-mediated dilation(NMD)of the brachial artery,and serum levels of biomarkers[nitric oxide(NO),endothelin-1(ET-1)]were compared before and after treatment.The incidence of adverse reac-tions during treatment was also monitored.Results After treatment,both groups showed significant reductions in blood pressure,blood glucose parameters,and ET-1 levels compared to baseline.The experimental group demon-strated significantly lower values in these assessments at the same time points than control group(P<0.05).Con-versely,FMD,NMD,and NO levels increased significantly in both groups after treatment,with experimental group showing significantly higher values than control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The combination of sitagliptin-metformin compound preparation and nifedipine significantly enhanced blood pressure control and blood glucose control and exerted a positive regulatory effect on vascular endothelial function in patients with T2DM and hyper-tension,demonstrating high clinical value for widespread application.[S Chin J Cardiol 2025;26(4):276-283]