Orthostatic hypotension, an often-neglected problem in community-dwelling older people: discrepancies between studies and real life
Sarah Damanti
Dario Consonni
Annalisa Valentini
Benedetta Cerasoli
Martina Biotto
Federica Conti
Marta Clerici
Pasqualina Iannuzzi
Emanuela Manzo
Paolo D Rossi
Simona Ciccone
Matteo Cesari
摘要：Orthostatic hypotension (OH) is a common condition in older persons.According to the 2011 criteria,OH is defined by a sustained reduction of systolic blood pressure of 20 mmHg or a 10 mmHg-fall of diastolic blood pressure.[1] Its prevalence increases with age and according to a recent systematic review the pooled prevalence in community dwelling older people is 22.2％.[2] Although OH is largely explained by concurrent clinical conditions (in particular,hypertension,diabetes,malnutrition,vascular encephalopathy,anemia,Parkinson's disease)[3],aging per se determines a series of physiological dysfunctions potentially representing its biological substratum (e.g.,reduction in baroreflex-mediated cardiovascular function,altered salt and water balance at renal level,impaired cardiac diastolic filling).It is also noteworthy that age-related changes in pharmacokinetic and pharmacodynamic mechanisms of drugs (especially in the context of polypharmacy) also increase the risk of OH.
机标关键词：
论文发表日期：2018-10-26
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 644-646 )
英文信息