Irregular surface of carotid atherosclerotic plaque is associated with ischemic stroke: a magnetic resonance imaging study
Dan ZHOU1
Jin LI2
Dong LIU2
Li-Ya JI1
Na-Qin WANG1
Jie DENG1
Ji-Chen WANG1
Min YE3
Xi-Hai ZHAO4
1.Department of Radiology, BenQ Medical Center, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China2.Department of Radiology, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China3.Department of Neurology, BenQ Medical Center, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China4.Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China
摘要：Objective To determine the association between the irregularity of carotid plaque surface using multidimensional magnetic resonance imaging (MRI) of ipsilateral acute cerebral infarction (ACI) cases.Methods Patients with recent cerebrovascular symptoms (stroke or transient ischemic attack ＜ 2 weeks) and atherosclerotic plaque in at least one carotid artery were diagnosed by B-mode ultrasound imaging (intima-media thickness ≥ 1.5 mm) and recruited for the present study.Irregular surface was defined when plaque surface was uneven with high and low fluctuation or plaque with surface ulceration.The irregularity of carotid plaque surface was determined on axial or oblique images alone (single-dimension) and on both axial images and oblique images (multidimensions),separately.Univariate and multivariate logistic regression analyses were performed to calculate the odds ratio (OR) and the corresponding 95％ CI of the irregular plaque surface in discriminating the presence of ipsilateral ACI.Results A total of 217 included subjects (mean age:60.7 ± 10.2 years,149 men) were recruited and 89 (41.0％),88 (40.6％) and 118 (54.4％) of them exhibited irregular plaque surface on axial,oblique and multidimensional MR images,respectively.The OR of irregularity of the plaque surface was determined by multidimensional MRI to be 5.88 (95％ CI:3.16-1 0.96,P ＜ 0.001) in discriminating the presence of ipsilateral ACI.Following adjustment for clinical confounding factors,this association remained statistically significant (OR =5.65,95％ CI:2.53-12.60,P ＜ 0.001).The analysis included further adjustment for the presence of lipid-rich necrotic core,intraplaque hemorrhage and stenosis and the results included that this association also remained statistically significant (OR =6.08,95％ CI:2.52-14.68,P ＜ 0.001).Conclusions The irregular plaque surface was determined by multidimensional MRI as an independent indicator for ipsilateral acute cerebral infarction.
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论文发表日期：2019-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 872-879 )
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