Age-specific outcomes after transcatheter left atrial appen-dage occlusion with the watchman device
Ritu Yadav1
Sia Savant2
Meghana Prakash2
H.Waraich2
Abhishek C.Sawant2
1.Midwestern University GME Consortium/Verde Valley Medical Center2.Structural Heart and Interventional Cardi-ology,University of Arizona School of Medicine,DHMG Cardiology-Chandler,Chandler,USA
摘要：Background Transcatheter left atrial appendage occlusion(LAAO)has become a suitable alternative to anticoagulation in pa-tients with atrial fibrillation(AF).However,outcomes among patients age＞75 years undergoing LAAO are lacking.
Methods We included 723 consecutive patients with AF undergoing LAAO from August 2015 to March 2020.Patient data in-cluding clinical,laboratory,procedural characteristics,medications and outcomes were collected.The primary composite out-come was major adverse cardiac events(MACE)including mortality,stroke,bleeding and readmissions at 60-days.
Results Mean age was 75±8 years and 434(60％)were males.Median CHA2DS2-VASc score was 4(IQR:4,5)points and medi-an HASBLED score was 4(IQR:3,4)points.Composite MACE outcome was significantly higher among patients age＞75 years in both unadjusted(17.1％vs.11.5％,P=0.03)and adjusted(Odds Ratio=1.59,95％CI:1.02-2.46,P=0.04)analysis.Composite MACE was primarily driven by higher all-cause mortality(1.3％vs.0,P=0.04)among patients age＞75 years.The secondary outcome of procedural success was also lower among patients age＞75 years(92.2％vs.96.2％,P=0.02).The occurrence of stroke(P=0.38),major bleeding(P=0.29)and readmissions(P=0.15)did not differ between patients age＞75 years and less than 75 years.
Conclusion Patients age＞75 years undergoing LAAO have worse outcomes primarily driven by higher all-cause mortality and are less likely to achieve procedural success.Future prospective studies evaluating these findings are warranted.
机标关键词：watchmandeviceafterwithage-specificappen-dageatrialleft
论文发表日期：2025-07-30
在线出版日期：2025-09-16（本平台首次上网日期，不代表文献的发表时间）
页数：8( 648-655 )