The systemic inflammatory response index as a risk factor for all-cause and cardiovascular mortality among individu-als with coronary artery disease:evidence from the cohort study of NHANES 1999-2018
Dao-Shen LIU1
Dan LIU2
Hai-Xu SONG2
Jing LI2
Miao-Han QIU2
Chao-Qun MA2
Xue-Fei MU2
Shang-Xun ZHOU1
Yi-Xuan DUAN1
Yu-Ying LI2
Yi LI
Ya-Ling HAN1
1.State Key Laboratory of Frigid Zone Cardiovascular Disease,Department of Cardiology,General Hospital of North-ern Theater Command,Shenyang,Liaoning,China;Department of Cardiology,Xijing Hospital,Air Force Medical University,Xi'an,Shaanxi,China2.State Key Laboratory of Frigid Zone Cardiovascular Disease,Department of Cardiology,General Hospital of North-ern Theater Command,Shenyang,Liaoning,China
摘要：Background The association of systemic inflammatory response index(SIRI)with prognosis of coronary artery disease(CAD)patients has never been investigated in a large sample with long-term follow-up.This study aimed to explore the association of SIRI with all-cause and cause-specific mortality in a nationally representative sample of CAD patients from United States.
Methods A total of 3386 participants with CAD from the National Health and Nutrition Examination Survey(NHANES)1999-2018 were included in this study.Cox proportional hazards model,restricted cubic spline(RCS),and receiver operating characteristic curve(ROC)were performed to investigate the association of SIRI with all-cause and cause-specific mortality.Piece-wise linear regression and sensitivity analyses were also performed.
Results During a median follow-up of 7.7 years,1454 all-cause mortality occurred.After adjusting for confounding factors,higher lnSIRI was significantly associated with higher risk of all-cause(HR=1.16,95％CI:1.09-1.23)and CVD mortality(HR=1.17,95％CI:1.05-1.30)but not cancer mortality(HR=1.17,95％CI:0.99-1.38).The associations of SIRI with all-cause and CVD mortality were detected as J-shaped with threshold values of 1.05935 and 1.122946 for SIRI,respectively.ROC curves showed that lnSIRI had robust predictive effect both in short and long terms.
Conclusions SIRI was independently associated with all-cause and CVD mortality,and the dose-response relationship was J-shaped.SIRI might serve as a valid predictor for all-cause and CVD mortality both in the short and long terms.
机标关键词：nhanesstudyindexriskwithfromall-causeamong
论文发表日期：2025-07-30
在线出版日期：2025-09-16（本平台首次上网日期，不代表文献的发表时间）
页数：10( 668-677 )