Global,regional,and national epidemiology of cardiovascular diseases attributable to physical inactivity among adults aged 70 years and older from 1990 to 2021
Cao WANG1
Ben-Jun ZHOU2
Wei GAO3
Yi-Min LI4
1.Department of Geriatrics,Sir Run Run Hospital,Nanjing Medical University,Nanjing,China2.Department of Cardiolo-gy,the Second Affiliated Hospital of Nanjing Medical University,Nanjing,China3.Department of Geriatrics,Sir Run Run Hospital,Nanjing Medical University,Nanjing,China;Department of Geriatrics,Zhongda Ho-spital,School of Medicine,Southeast University,Nanjing,China4.Department of Cardiology,Sir Run Run Hospital,Nan-jing Medical University,Nanjing,China
摘要：BACKGROUND Physical inactivity is a significant yet underappreciated risk factor for cardiovascular disease(CVD),particularly among older adults.The aim of this study was to analyze the global burden of CVD attributable to physical inactivity in individuals ag-ed 70 years and older from 1990 to 2021 using the Global Burden of Disease data.
METHODS We assessed trends in disability-adjusted life years(DALYs)and deaths,decomposed changes into population growth,ag-ing,and epidemiological factors,and examined health inequalities across sociodemographic index(SDI)regions.
RESULTS From 1990 to 2021,a substantial rise in DALYs was observed,especially in low and middle SDI regions,with a 120.06％in-crease in the low SDI region,but a 23.10％decline in the high SDI region.Decomposition analysis identified population aging and gro-wth as primary drivers for the burden,contributing 66.39％and 83.56％to the increase in middle and low SDI regions,respectively.By con-trast,epidemiological improvements alleviated burden in the high SDI region(54.91％).Gender disparities persisted,with women exper-iencing a higher burden.Inequality analysis indicated a shift in CVD burden towards the low SDI region,with declining concentration indices for DALYs(—0.03 to-0.13)and deaths(-0.07 to—0.15).The Bayesian age-period-cohort projections suggest continued increas-es in DALYs and deaths through 2050,with women disproportionately affected.
CONCLUSIONS These findings highlight the urgent need for targeted interventions promoting physical activity,improving healt-hcare access,and implementing region-specific prevention strategies.
机标关键词：epidemiologyregionalnationalglobalphysicalfromadultsaged
论文发表日期：2025-08-30
在线出版日期：2025-09-22（本平台首次上网日期，不代表文献的发表时间）
页数：16( 709-724 )