Chronic heart failure with reduced and mildly reduced left ventricle ejection fraction:relationship between mitochon-drial respiratory dysfunction of peripheral blood mononu-clear cells and iron deficiency
Alla A Garganeeva
Viacheslav A.Korepanov
Elena A Kuzheleva
Olga V Tukish
Karina N Vitt
Elvira F Muslimova
Sergey A Afanasiev
Cardiology Research Institute,Tomsk National Research Medical Center,Russian Academy of Sciences,Tomsk,Russia
摘要：Objectives To compare respiratory parameters of peripheral blood mononuclear cell mitochondria and iron metabolism indic-ators in patients with different NYHA functional classes of ischemic heart failure(HF).
Methods This single center,prospective,non-blinded study enrolled 20 patients with diagnosed chronic HF of ischemic genes-is with reduced and mildly reduced left ventricle ejection fraction.The maximum oxygen consumption at the peak of the exercise test(VO2 peak),iron metabolism parameters and respiratory activity of peripheral blood mononuclear cell mitochondria were as-sessed.
Results Among the patients,a half of individuals were diagnosed with iron deficiency.Subgroups of patients with different HF severity did not significant differ in VO2 peak(P=0.209),serum iron(P=0.468)and ferritin(P=0.235)levels.But there was a trend in increasing in these parameters with increasing NYHA HF functional class.Respiratory control coefficient(RC)in NAD-dependent and FAD-dependent mitochondrial oxidation were lower in patients with NYHA HF Ⅲ functional class compared to individuals with NYHA HF I functional class(P=0.028 and P=0.040,respectively).Serum iron(P=0.026),ferritin(P=0.045)levels,transferrin saturation(P=0.006)were negatively correlated with RC in NAD-dependent mitochondrial oxidation.
Conclusions In aggravation of ischemic HF NYHA FC,there is a decrease in RC of PBMC mitochondria during the oxidation of NAD-dependent and FAD-dependent substrates.In the whole sample,patients with laboratory-confirmed iron deficiency ac-counted a half of the total number.Iron metabolism parameters had a paradoxical inverse relationship with the level of RC in PB-MC mitochondria of patients with HF.
机标关键词：relationshipfractionbetweencellsheartbloodwithchronic
论文发表日期：2025-09-30
在线出版日期：2025-11-14（本平台首次上网日期，不代表文献的发表时间）
页数：6( 812-817 )