Performance of angiographic quantitative flow ratio in guid-ing coronary interventions across different age groups:pres-pecified subgroup analysis of the FAVOR Ⅲ China trial
Xin-Ye XU1
Li-Yun HE1
Chang-Dong GUAN2
Ming CUI1
Yu-Peng WANG1
Yu-Jie ZHOU3
Jian-An WANG4
Jun BU5
Liang-Long CHEN6
Xin-Kai QU7
Jun-Qing YANG8
Yan-Yan ZHAO9
Xue-Bo LIU10
Cheng-Xing SHEN11
Sheng-Xian TU12
Gregg STONE13
Li-Jun GUO1
Lei SONG2
1.Department of Cardiology,Beijing Anzhen Hospital,C2.Department of Cardiology,Second Affiliated Hospita3.Department of Cardiology,Peking University Third H4.Department of Cardiology,Fuwai Hospital,National C5.Department of Cardiology,Renji Hospital,School of 6.Department of Cardiology,Fujian Medical University7.Department of Cardiology,Huadong Hospital Affiliat8.Department of Cardiology,Guangdong Provincial Peop9.Medical Research and Biometrics Centre,National Ce10.Depart-ment of Cardiology,Tongji Hospital,Tongji U11.Department of Cardi-ology,Shanghai Jiao Tong Unive12.Biomedical Instrument In-stitute,School of Biomedi13.The Zena and Michael A.Wiener Cardiovascular Insti
摘要：Background Quantitative flow ratio(QFR)based lesion selection for percutaneous coronary intervention(PCI)treatment has shown clinical benefits in terms of reduced risk for myocardial infarction and repeat revascularization.Whether this benefit is consistent across different age groups still needs further investigation.
Methods In this prespecified subgroup study of FAVOR III China trial,we compared long-term clinical outcomes between QFR-guided and angiography-guided PCI among different age groups among 3825 enrolled subjects.The primary endpoint was major adverse cardiac events(MACEs),a composite of all-cause death,myocardial infarction,and ischemia-driven revasculariza-tion.
Results Of the 3825 patients,1717(44.9%)were aged≥65 years.At baseline,patients≥65 had higher rates of hypertension,hy-perlipidaemia,stroke history(P<0.0001),and peripheral vascular disease(P=0.024)and had higher SYNTAX scores(P=0.0095).Compared with standard angiography guidance,the QFR-guided strategy consistently reduced the 1-year(≥65 years,6.04%vs.9.19%,HR=0.65,95%CI:0.46-0.92;<65 years,5.53%vs.8.43%,HR=0.65,95%CI:0.47-0.91)and 3-year MACE rates in both age groups(≥65 years,11.8%vs.15.2%,HR:0.75,95%CI:0.58-0.98;<65 years,9.5%vs.14.6%,HR=0.63;95%CI:0.49-0.81),without a significant interaction(Pinteraction=0.99).Within the QFR-guided group,the 3-year MACE rate in patients with deferred vessels was numerically greater in patients aged≥65 years than in those aged<65 years(8.3%vs.3.0%,P=0.10).
Conclusions Although with higher rate of comorbidities and more complex coronary anatomy,the long-term benefit of the QFR-guided PCI strategy remained consistent in patients≥65 years,compared with those<65 years.
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论文发表日期：2025-11-30
在线出版日期：2026-01-09（本平台首次上网日期，不代表文献的发表时间）
页数：13( 887-899 )