Evaluating the association between oral microbiota and cardiovascular diseases:evidence from Mendelian rando-mization analysis
Si-Da QIN
Yi-Wen ZHANG
Jing-Zhi WANG
Department of Cardiology,the First Affiliated Hospital of Harbin Medical University,Harbin,China
摘要：Background Recent studies have suggested a potential role of the oral microbiome in the development of cardiovascular dis-eases.This study aims to investigate the association between oral microbiota and cardiovascular disease risk,including atrial fib-rillation,myocardial infarction,chronic heart failure,and hypertension.
Methods We analyzed GWAS data from East Asian populations'oral microbiome,involving 2,017 tongue and 1,915 saliva samples from 2,984 individuals with whole-genome sequencing.Additionally,we sourced cardiovascular disease GWAS data from NBDC,including atrial fibrillation(8,180 cases,28,621 controls),myocardial infarction(14,992 cases,146,214 controls),chronic heart failure(10,540 cases,168,186 controls),and systolic blood pressure(145,505 individuals).
Results Several oral microbiota taxa were found to be significantly associated with cardiovascular disease outcomes.Specific microbiota,such as Centipeda,Corynebacterium,and Pseudomonas E,were negatively correlated with heart failure.In contrast,taxa like Neisseria D and Actinomyces were associated with an increased risk of atrial fibrillation and myocardial infarction.Ad-ditionally,certain oral microbiota showed correlations with changes in blood pressure,highlighting their potential role in hyper-tension.
Conclusion Our findings suggest that the oral microbiota may influence the development and progression of cardiovascular diseases,providing new insights into the potential impact of oral health on cardiovascular risk.
机标关键词：associationanalysisbetweenoralfromcardiovasculardiseasesevaluating
论文发表日期：2026-01-30
在线出版日期：2026-03-16（本平台首次上网日期，不代表文献的发表时间）
页数：9( 36-44 )