From ancient herb to modern miracle:an in-depth analysis of the cardioprotective effects of artemisinin and its deriva-tives
Hao-Shuang LI1
Shu-Rong LI1
Wen-Jue LIU2
Yuan ZHANG2
Rui WU2
Xu-Yang CUI2
Jia-Zheng SUN2
You-Wei MA3
Ying ZHAO4
1.College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan,Shandong,China2.School of Medicine,Shandong University of Traditional Chinese Medicine,Jinan,Shandong,China3.Acu-puncture and Moxibustion and Massage College of Shandong University of Traditional Chinese Medicine,Jinan,Shan-dong,China4.Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,Shandong,China
摘要：Significant progress has been recently made in studying artemisinin and its derivatives for treating cardiovascu-lar diseases,making this area a prominent research focus.Artemisinin,discovered with great acclaim,was initially and widely adopted in antimalarial treatments.As scientific research steadily progressed,its latent potential role in the cardiovascular sys-tem gradually captured the attention of the global scientific community.Artemisinin and its derivatives can reportedly play a protective role in the cardiovascular system through various mechanisms,including anti-inflammatory,anti-angiogenic,antioxid-ant,and anti-fibrotic effects,as well as the regulation of blood lipids and blood pressure.In particular,they have shown prom-ising therapeutic effects in models of cardiovascular diseases such as atherosclerosis,myocardial ischaemia,and cardiac hyper-trophy.In addition,artemisinin and its derivatives can improve cardiovascular function and prevent cardiovascular injury by regulating signalling pathways closely related to cardiovascular disease,such as AMPK and NF-kB.Although numerous ex vivo and in vivo experiments have verified the potential role of artemisinin in treating cardiovascular diseases,systematic studies to comprehensively elucidate its specific mechanism of action remain scarce.Further exploration of the precise roles of artemisinin and its derivatives in cardiovascular disease therapy,along with their potential clinical applications,could offer valuable insights for future research and treatment strategies.
机标关键词：analysismodernfromcardardiancientartemisininderiva-tives
论文发表日期：2026-01-30
在线出版日期：2026-03-16（本平台首次上网日期，不代表文献的发表时间）
页数：20( 45-64 )