Prognostic value of left ventricular phenotypes by cardiac mag-netic resonance in elderly and non-elderly patients
Rungroj Krittayaphong1
Thammarak Songsangjinda2
Kanchalaporn Jirataiporn3
Ahthit Yindeengam3
1.Division of Cardiology,Department of Medicine,Faculty of Medicine Siriraj Hospital,Mahidol University,Bangkok,Thail-and2.Cardiology Unit,Division of Internal Medicine,Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand3.Her Majesty's Cardiac Center,Faculty of Medicine Siriraj Hospital,Mahidol University,Bangkok,Thailand
摘要：BACKGROUND Many conditions may affect left ventricular(LV)phenotypes which have been classified according to LV mass and geometry.There is limited data on the prognostic value of LV phenotypes classified by cardiac magnetic resonance(CMR).This study ai-med to determine the prognostic value of LV phenotypes in elderly and non-elderly patients with known or suspected coronary artery disease.
METHODS This is a retrospective cohort study among patients who underwent stress or viability CMR.LV phenotypes were classif-ied according to the LV mass index,the LV end-diastolic volume index and the LV mass/volume ratio,into normal,concentric remodel-ing,concentric hypertrophy,and eccentric hypertrophy.The primary outcome was a composite of death or heart failure.
RESULTS A total of 3289 patients was studied.The average age was 68.0±12.7 years,52.2%of patients were women.Elderly were de-fined as age≥65 years accounting for 63.9%of the cohort.LV phenotypes were normal,concentric remodeling,concentric hypertrop-hy,and eccentric hypertrophy at 74.5%,5.8%,9.2%,and 10.5%,respectively.The median duration of follow-up was 41.4 months.The com-posite outcome of death or heart failure occurred in 7.3%of patients.The prognostic impact of LV phenotypes was more pronounced in the elderly,with eccentric hypertrophy showing the worst prognosis,followed by concentric hypertrophy and concentric remodeling wi-th the adjusted hazard ratio(95%CI)of 2.37(1.72-3.25),1.53(1.12-2.08),and 1.14(0.76-1.71),respectively,compared to normal phenoty-pe.Patients with eccentric hypertrophy also demonstrated abnormal global longitudinal LV strain,left atrial strain,and extracellular vo-lume fraction.
CONCLUSIONS LV phenotypes by CMR independently predict adverse clinical outcomes in elderly patients with known or suspe-cted coronary artery disease.In non-elderly patients,the prognostic value of LV phenotypes was less evident.Assessment of LV phenoty-pes may be useful for risk stratification.
机标关键词：cardiacleftmag-neticnon-elderlypatientsphenotypesprognosticresonance
论文发表日期：2026-02-28
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：14( 69-82 )