Semaglutide ameliorates coronary microembolization-induced injury by suppressing apoptosis and inflammation via the HM-GB1/RAGE/NF-κB p65 pathway
Hua-Feng YANG1
Hong-Qing LI2
Qiang WANG2
Xian-Tao WANG2
Lang LI2
1.Cardiac Surgery Intensive Care Unit,The First Affiliated Hospital of Guangxi Medical University,Nanning,China2.De-partment of Cardiology,The First Affiliated Hospital of Guangxi Medical University,Nanning,China
摘要：BACKGROUND Coronary microembolization(CME)is the major leading cause of perioperative myocardial injury during coronary revascularization.Semaglutide exerts multiple protective biological activities,but its cardioprotective effects on CME remain unclear.Th-us,this experiment studied the impact of semaglutide on CME-induced myocardial injury.
METHODS A rat CME model was generated by injecting microspheres into the left ventricle while clamping the ascending aorta.A H9c2 cardiomyocyte model was constructed by stimulation of lipopolysaccharide combined with hypoxia.Semaglutide or the high mob-ility group box 1(HMGB1)antagonist glycyrrhizin administrations were ahead of CME and cell modeling.Cardiac function,myocardi-al injury markers,cell viability and morphological alternations were detected.Apoptotic and inflammatory factors,cytosolic HMGB1 and its translocation,advanced glycosylation end-product specific receptor(RAGE),and nuclear factor kappa B p65(NF-κB p65)were eval-uated.
RESULTS Semaglutide pretreatment ameliorated CME-induced cardiac systolic dysfunction and relieved the cardiac injury.Semaglu-tide attenuated myocardial apoptosis and inflammatory response following CME in vivo and in vitro.Moreover,semaglutide downregu-lated HMGB1 expression and suppressed its nuclear-cytoplasmic translocation.Both glycyrrhizin and semaglutide administration aff-ected the HMGB1/RAGE/NF-κB p65 pathway after CME.
CONCLUSIONS Semaglutide pretreatment attenuates CME-induced myocardial injury by suppressing apoptosis and inflammati-on through the HMGB1/RAGE/NF-κB p65 pathway.
机标关键词：apoptosispathwayrageamelioratescoronaryembolizationinducedinflammation
论文发表日期：2026-02-28
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：17( 83-99 )