Impact of heart failure on skeletal muscle:an overview
Lucian Batista de Oliveira1
Marina Baltar de Albuquerque2
Amalia Pinheiro Jácome Bezerra Cavalcanti2
Fábio Moura3
Francisco Bandeira2
1.Division of Endocrinology and Diabetes,Agamenon Magalhães Hospital,Faculty of Medical Sciences,University of Per-nambuco,Recife,Pernambuco,Brazil;Medical School,Federal University of Campina Grande,Campina Grande,Paraí-ba,Brazil2.Division of Endocrinology and Diabetes,Agamenon Magalhães Hospital,Faculty of Medical Sciences,University of Per-nambuco,Recife,Pernambuco,Brazil3.Endocrinology and Metabolism Department,University of Pernambuco,Recife,Pernambuco,Brazil
摘要：Heart failure(HF)is a complex clinical syndrome that promotes high morbidity and multi-systemic damage.Skeletal muscle can be directly affected by HF through a loss of physical capacity and various inflammatory,hormonal,and metabolic mechan-isms observed in this cardiac condition,which collectively contribute to a high prevalence of sarcopenia in HF patients.Therefore,the aim of this review was to compile the main recent clinical and epidemiological data on muscle health in HF patients.Nine studies we-re selected from systematic reviews and clinical trials,which demonstrated a high prevalence of sarcopenia in patients with HF,par-ticularly in males,hospitalized patients,the elderly,and those with HF with reduced ejection fraction.Oxidative stress markers and hig-her levels of natriuretic peptides were also observed in HF patients who exhibited damaged muscle parameters.Furthermore,the ove-rall deterioration of prognosis in HF was associated with criteria defining sarcopenia,such as low muscle strength and lean mass loss.Th-ese findings reinforce the importance of evaluating skeletal muscle in HF patients,which can provide improvements in morbidity and functionality.
机标关键词：overviewimpactheartfailuremuscleskeletal
论文发表日期：2026-02-28
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：8( 113-120 )