Long noncoding RNA lnc_217 regulates hepatic lipid metabolism by modulating lipogenesis and fatty acid oxidation
Xiaoqing Yuan1
Yawei Liu1
Xule Yang1
Yun Huang1
Xuan Shen1
Hui Liang2
Hongwen Zhou3
Qian Wang1
Xu Zhang1
John Zhong Li1
1.The Key Laboratory of Rare Metabolic Disease,Department of Biochemistry and Molecular Biology,the Key Laboratory of Human Functional Genomics of Jiangsu Province,Key Laboratory of Targeted Intervention of Cardiovascular Disease,Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of General Surgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China3.Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China
摘要：Nonalcoholic fatty liver disease(NAFLD)is considered a major health epidemic with an estimated 32.4%worldwide prevalence.No drugs have yet been approved and therapeutic nodes remain a major unmet need.Long noncoding RNAs are emerging as an important class of novel regulators influencing multiple biological processes and the pathogenesis of NAFLD.Herein,we described a novel long noncoding RNA,lnc_217,which was liver enriched and upregulated in high-fat diet-fed mice,and a genetic animal model of NAFLD.We found that liver specific knockdown of lnc_217 was resistant to high-fat diet-induced hepatic lipid accumulation and decreased serum lipid in mice.Mechanistically,we demonstrated that knockdown of lnc_217 not only decreased de novo lipogenesis by inhibiting sterol regulatory element binding protein-1c cleavage but also increased fatty acid β-oxidation through activation of peroxisome proliferator-activated receptor α and carnitine palmitoyltransferase-1α.Taken together,we conclude that lnc_217 may be a novel regulator of hepatic lipid metabolism and a potential therapeutic target for the treatment of hepatic steatosis and NAFLD-related metabolic disorders.
机标关键词：oxidationlongacidfattyhepaticlipidlipogenesismetabolism
分类号：R575.5(消化系及腹部疾病)
论文发表日期：2023-11-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：13( 中插3,448-459 )
英文信息