Histone lactylation promotes cell proliferation,migration and invasion through targeting HMGB1 in endometriosis
Jie Chen1
Pengfei Qin1
Yanli Sun1
Suping Han2
1.Department of Obstetrics and Gynecology,Women's Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing,Jiangsu 210004,China2.Department of Gynecology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210004,China
摘要：Endometriosis is defined as a condition with endometrium-like tissues migrating outside of the pelvic cavity.However,the mechanism of endometriosis is still unclear.Lactate can be covalently modified to lysine residues of histones and other proteins,which is called lactylation.The results showed that the higher level of lactate and lactate dehydrogenase A enhanced the histone H3 lysine 18 lactylation(H3K18lac)in ectopic endometrial tissues and ectopic endometrial stromal cells than that in normal endometrial tissues and normal endometrial stromal cells.Lactate promoted cell proliferation,migration,and invasion in endometriosis.Mechanistically,lactate induced H3K18lac to promote the expression of high-mobility group box 1(HMGB1)in endometriosis,and HMGB1 knockdown significantly reduced the cell proliferation,migration,and invasion of the lactate-treated cells through the phosphorylation of AKT.In conclusion,lactate could induce histone lactylation to promote endometriosis progression by upregulating the expression of HMGB1,which may provide a novel target for the prevention and treatment of endometriosis.
机标关键词：hmgb1throughcellendometriosishistoneinvasionlactylationmigration
分类号：R711.71(妇科学)
论文发表日期：2023-11-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：10( 中插5,470-478 )
英文信息