Association of maternal hypertensive disorders in pregnancy with infant neurodevelopment
Bo Huang1
Yifan Wang2
Yangqian Jiang3
Hong Lv4
Tao Jiang5
Yun Qiu4
Qun Lu2
Jiangbo Du4
Yuan Lin6
Hongxia Ma4
1.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Maternal,Child and Adolescent Health,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China3.Department of Maternal,Child and Adolescent Health,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China4.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;State Key Laboratory of Reproductive Medicine(Suzhou Centre),the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University,Suzhou,Jiangsu 215002,China5.Department of Biostatistics,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China6.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Maternal,Child and Adolescent Health,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;State Key Laboratory of Reproductive Medicine(Suzhou Centre),the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University,Suzhou,Jiangsu 215002,China
摘要：Inconsistent findings have been reported regarding the associations between hypertensive disorders in pregnancy(HDP)and infant neurodevelopment.Leveraging data from the Jiangsu Birth Cohort,in the present study,we re-visited such associations in one-year-old infants from 2 576 singleton pregnancies and 261 twin pregnancies.We first assessed infant neurodevelopment by the Bayley Scales of Infant and Toddler Development Screening Test(the Third Edition),and then estimated its association with maternal HDP using general linear regression models and Poisson regression models.In singleton pregnancies,compared with mothers unexposed to HDP,infants born to mothers with chronic hypertension exhibited a lower score(β,-0.67;95%confidence interval[CI],-1.19--0.15)and a higher risk of"non-optimal"gross motor development(risk ratio[RR],2.21;95%CI,1.02-4.79);in twin pregnancies,infants born to mothers with HDP exhibited lower scores in cognition(β,-0.49;95%CI,-0.96--0.01),receptive communication(β,-0.55;95%CI,-1.03--0.06),and gross motor(β,-0.44;95%CI,-0.86--0.03),and at a higher risk of"non-optimal"gross motor development(RR,2.12;95%CI,1.16-3.88).These findings indicate that infants born to mothers with HDP may have inferior neurodevelopment outcomes at the age of one year.
机标关键词：associationdevelopmentneurodwithdisordershypertensiveinfantmaternal
分类号：R714.51(产科学)R714.246(产科学)
论文发表日期：2023-11-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：14( 中插6,479-491 )
英文信息