Effect of remimazolam vs.propofol on hemodynamics during general anesthesia induction in elderly patients:Single-center,randomized controlled trial
Mingfeng He
Chanjuan Gong
Yinan Chen
Rongting Chen
Yanning Qian
Department of Anesthesiology and Perioperative Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China
摘要：The current study aimed to compare the effects between remimazolam and propofol on hemodynamic stability during the induction of general anesthesia in elderly patients.We used propofol at a rate of 60 mg/(kg·h)in the propofol group(group P)or remimazolam at a rate of 6 mg/(kg·h)in the remimazolam group(group R)for the induction.A processed electroencephalogram was used to determine whether the induction was successful and when to stop the infusion of the study drug.We measured when patients entered the operating room(T0),when the induction was successful(T1),and when before(T2)and 5 min after successful endotracheal intubation(T3).We found that mean arterial pressure(MAP)was lower at T1-3,compared with T0 in both groups,but higher at T2 in the group R,while ΔMAPT0-T2 and ΔMAPmax were smaller in the group R(ΔMAPT0-T2:the difference between MAP at time point T0 and T2,ΔMAPmax:the difference between MAP at time point T0 and the lowest value from T0 to T3).Cardiac index and stroke volume index did not differ between groups,whereas systemic vascular resistance index was higher at T1-3 in the group R.These findings show that remimazolam,compared with propofol,better maintains hemodynamic stability during the induction,which may be attributed to its ability to better maintain systemic vascular resistance levels.
机标关键词：trialanesthesiacontrolledduringeffectelderlygeneralhemodynamics
分类号：R614(外科手术学)
论文发表日期：2024-01-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：11( 中插5,66-75 )
英文信息