Drug resistance mechanisms in cancers:Execution of pro-survival strategies
Pavan Kumar Dhanyamraju
Fels Cancer Institute of Personalized Medicine,Lewis-Katz School of Medicine,Temple University,Philadelphia,PA 19140,USA
摘要：One of the quintessential challenges in cancer treatment is drug resistance.Several mechanisms of drug resistance have been described to date,and new modes of drug resistance continue to be discovered.The phenomenon of cancer drug resistance is now widespread,with approximately 90%of cancer-related deaths associated with drug resistance.Despite significant advances in the drug discovery process,the emergence of innate and acquired mechanisms of drug resistance has impeded the progress in cancer therapy.Therefore,understanding the mechanisms of drug resistance and the various pathways involved is integral to treatment modalities.In the present review,I discuss the different mechanisms of drug resistance in cancer cells,including DNA damage repair,epithelial to mesenchymal transition,inhibition of cell death,alteration of drug targets,inactivation of drugs,deregulation of cellular energetics,immune evasion,tumor-promoting inflammation,genome instability,and other contributing epigenetic factors.Furthermore,I highlight available treatment options and conclude with future directions.
机标关键词：strategiescancersdrugexecutionmechanismspro-survivalresistance
分类号：R73(肿瘤学)
论文发表日期：2024-03-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：28( 前插1,95-121 )
英文信息