Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain
Kannan Sridharan1
Shamik Shah2
Mona Al Hammad3
Fatima Ali Mohammed4
Sindhan Veeramuthu1
Mona Abdulla Taher4
Mustafa Mohamed Hammad3
Lamees Jawad5
Eman Farid6
1.Department of Pharmacology and Therapeutics,College of Medicine and Medical Sciences,Arabian Gulf University,Manama,Kingdom of Bahrain2.Department of Nephrology,Salmaniya Medical Complex,Manama,Kingdom of Bahrain;Department of Internal Medicine,College of Medicine and Medical Sciences,Arabian Gulf University,Manama,Kingdom of Bahrain3.Salmaniya Medical Complex,Manama,Kingdom of Bahrain4.Department of Nephrology,Salmaniya Medical Complex,Manama,Kingdom of Bahrain5.Department of Laboratory Medicine,Salmaniya Medical Complex,Manama,Kingdom of Bahrain6.Department of Laboratory Medicine,Salmaniya Medical Complex,Manama,Kingdom of Bahrain;Department of Microbiology,Immunology,and Infectious Diseases,College of Medicine and Medical Sciences,Arabian Gulf University,Manama,Kingdom of Bahrain
摘要：Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for treatment.Serum creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney function.Here,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney function.We used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 m2.We observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum creatinine.The estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all equations.Serum KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 m2).We observed a significant correlation between serum creatinine and Cys C in our renal transplant patients.Therefore,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.
机标关键词：cystatinbetweenkidneyessastudyantsbahraincorrelations
分类号：R699.2(泌尿科学（泌尿生殖系疾病）)
论文发表日期：2024-05-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：10( 中插7,269-277 )
英文信息