Genetic variants in C1GALT1 are associated with gastric cancer risk by influencing immune infiltration
Mengfan Guo1
Jingyuan Liu2
Yujuan Zhang2
Jingjing Gu2
Junyi Xin3
Mulong Du4
Haiyan Chu2
Meilin Wang2
Hanting Liu2
Zhengdong Zhang1
1.Departments of Environmental Genomics and Genetic Toxicology,the Key Laboratory of Modern Toxicology of Ministry of Education,Center for Global Health,Jiangsu Key Laboratory of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,School of Public Health;Institute of Clinical Research,the Affiliated Taizhou People's Hospital of Nanjing Medical University,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Departments of Environmental Genomics and Genetic Toxicology,the Key Laboratory of Modern Toxicology of Ministry of Education,Center for Global Health,Jiangsu Key Laboratory of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China3.Department of Bioinformatics,School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing,Jiangsu 211166,China4.Departments of Environmental Genomics and Genetic Toxicology,the Key Laboratory of Modern Toxicology of Ministry of Education,Center for Global Health,Jiangsu Key Laboratory of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Department of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
摘要：Core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1(C1GALT1)is known to play a critical role in the development of gastric cancer,but few studies have elucidated associations between genetic variants in C1GALT1 and gastric cancer risk.By using the genome-wide association study data from the database of Genotype and Phenotype(dbGAP),we evaluated such associations with a multivariable logistic regression model and identified that the rs35999583 G>C in C1GALT1 was associated with gastric cancer risk(odds ratio,0.83;95%confidence interval[CI],0.75-0.92;P=3.95×10-4).C1GALT1 mRNA expression levels were sig-nificantly higher in gastric tumor tissues than in normal tissues,and gastric cancer patients with higher C1GALT1 mRNA levels had worse overall survival rates(hazards ratio,1.33;95%CI,1.05-1.68;Plog-rank=1.90×10-2).Furthermore,we found that C1GALT1 copy number differed in various immune cells and that C1GALT1 mRNA expression levels were positively correlated with the infiltrating levels of CD4+T cells and macrophages.These results suggest that genetic variants of C1GALT1 may play an important role in gastric cancer risk and provide a new insight for C1GALT1 into a promising predictor of gastric cancer susceptibility and immune status.
机标关键词：c1galt1geneticcancerriskwithassociatedgastricimmune
分类号：R735.2(消化系肿瘤)
论文发表日期：2024-07-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：11( 中插5,348-357 )
英文信息