Ferroptosis:Iron-mediated cell death linked to disease pathogenesis
Xiangyu Zhang1
Yingchao Hu1
Bingwei Wang2
Shuo Yang1
1.Department of Immunology,State Key Laboratory of Reproductive Medicine,Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Personalized Cancer Medicine,Gusu School,the Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi People's Hospital,Wuxi Medical Center,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China
摘要：Ferroptosis is a pattern of iron-mediated regulatory cell death characterized by oxidative damage.The molecular regulatory mechanisms are related to iron metabolism,lipid peroxidation,and glutathione metabolism.Additionally,some immunological signaling pathways,such as the cyclic GMP-AMP synthase-stimulator of the interferon gene axis,the Janus kinase-signal transducer and activator of transcription 1 axis,and the transforming growth factor beta 1-Smad3 axis,may also participate in the regulation of ferroptosis.Studies have shown that ferroptosis is significantly associated with many diseases such as cancer,neurodegenerative diseases,inflammatory diseases,and autoimmune diseases.Considering the pivotal role of ferroptosis-regulating signaling in the pathogenesis of diverse diseases,the development of ferroptosis inducers or inhibitors may have significant clinical potential for the treatment of aforementioned conditions.
机标关键词：ferroptosiscelldeathdiseaseiron-mediatedlinkedpathogenesis
分类号：R329.25(人体形态学)
论文发表日期：2024-09-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：24( 前插1,413-435 )
英文信息