Piezo1 as a potential player in intracranial hemorrhage:From perspectives on biomechanics and hematoma metabolism
Tianle Jin1
Maoxing Fei2
Shiqiao Luo3
Handong Wang1
1.Department of Neurosurgery,Nanjing BenQ Medical Center,the Affiliated BenQ Hospital of Nanjing Medical University,Nanjing,Jiangsu 210019,China2.Department of Neurosurgery,Nanjing Jinling Hospital,the Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu 210002,China3.Department of Neurosurgery,the Affiliated Jinling Hospital of Nanjing Medical University,Nanjing,Jiangsu 210002,China
摘要：Intracranial hemorrhage(ICH)causes numerous neurological deficits and deaths worldwide each year,leaving a significant health burden on the public.The pathophysiology of ICH is complicated and involves both primary and secondary injuries.Hematoma,as the primary pathology of ICH,undergoes metabolism and triggers biochemical and biomechanical alterations in the brain,leading to the secondary injury.Past endeavors mainly aimed at biochemical-initiated mechanisms for causing secondary injury,which have made limited progress in recent years,although ICH itself is also highly biomechanics-related.The discovery of the mechanically-activated cation channel Piezo1 provides a new avenue to further explore the mechanisms underlying the secondary injury.The current article reviews the structure and gating mechanisms of Piezo1,its roles in the physiology/pathophysiology of neurons,astrocytes,microglia,and bone-marrow-derived macrophages,and especially its roles in erythrocytic turnover and iron metabolism,revealing a potential interplay between the biomechanics and biochemistry of hematoma in ICH.Collectively,these advances provide deeper insights into the secondary injury of ICH and lay the foundations for future research.
机标关键词：piezo1playerfrombiomechanicshematomahemorrhageintracranialmetabolism
分类号：R743.34(神经病学与精神病学)
论文发表日期：2024-09-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：13( 中插1,436-447 )
英文信息