Unlocking the novel activation mechanism of human IL-18
Yingchao Hu1
Yuxian Song2
Shuo Yang1
1.The Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi People's Hospital,Wuxi Medical Center,Department of Immunology,State Key Laboratory of Reproductive Medicine and Offspring Health,Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Personalized Cancer Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of Immunology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China
摘要：Interleukin (IL)-18,a member of the IL-1 family,is commonly known as an interferon-γ inducer and is expressed in both hematopoietic and non-hematopoietic cells,such as intestinal epithelial cells,keratinocytes,and endothelial cells. In the immune system,the mature IL-18 plays a critical role in eliminating tumors and infectious agents by activating NK cells and T-lymphocytes,and by synergizing with other cytokines like IL-12 and IL-1β to induce inflammation[1-2]. However,excessive activation of IL-18 may cause a variety of immune-inflammatory diseases,including psoriasis,atherosclerosis,Alzheimer's disease,and inflammatory bowel disease[3-4]. Regarding the activation mechanism of IL-18,similar to immune cells,mouse non-immune cells rely on caspase-1 for its processing and maturation.However,the activation mechanism of IL-18 in human non-immune cells remains unclear.
机标关键词：mechanismhumannovelactivationunlocking
分类号：R392(医学免疫学)
论文发表日期：2024-09-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：4( 中插2,448-450 )