Association of exposure to per-and polyfluoroalkyl substances with liver injury in American adults
Yuqian Yan1
Lu Zhang1
Xin Xu2
Jing Lu1
Xinyuan Ge2
Maojie Liu2
Juan Yang1
Chan Tian1
Zijun Ge3
Chengxiao Yu2
Wen Guo4
Chunyan Ye5
Qun Zhang4
1.Health Management Center,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China;Department of Epidemiology,China International Cooperation Center on Environment and Human Health,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of Epidemiology,China International Cooperation Center on Environment and Human Health,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China3.Office of Infection Management,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China4.Health Management Center,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China5.Department of Liver Diseases,the Third People's Hospital of Changzhou,Changzhou,Jiangsu 213000,China
摘要：Epidemiological data are scarce regarding the association of exposure to mixtures of per-and polyfluoroalkyl substances(PFASs)with liver injury in the general population.In the current study,therefore,we examined data from the National Health and Nutrition Examination Survey(2009-2018).The PFAS exposure levels were defined by the serum concentrations of PFASs with over 70%detection in samples,namely perfluorooctanoic acid,perfluorononanoic acid,perfluorohexane sulfonic acid,perfluorodecanoic acid,and perfluorooctane sulfonic acid(PFOS).We evaluated liver injury from two aspects:first,the degree of liver inflammation was determined based on levels of the serum alanine aminotransferase,aspartate aminotransferase,glutamyltransferase,and total bilirubin;second,the degree of liver fibrosis was determined based on the fibrosis-4 index.We assessed the associations of individual or total PFAS exposure with these liver injury outcomes using multivariable linear and logistic regression models,restricted cubic splines,and weighted quantile sum regression.Among the samples of 7 484 American adults,the median concentration of PFOS was the highest,followed by perfluorooctanoic acid and perfluorohexane sulfonic acid.Using multivariable linear regression,we observed positive correlations between all PFAS exposure and liver enzyme levels,such as alanine aminotransferase,aspartate aminotransferase,and total bilirubin.Additionally,the weighted quantile sum model indicated an overall positive association between exposure to the five PFASs and liver injury risk.For liver function biomarkers and liver fibrosis,perfluorononanoic acid and PFOS were the most heavily weighted chemicals,respectively.Our findings provide new epidemiological evidence indicating potential associations between PFAS exposure and adverse effects on liver injury biomarkers,highlighting the potentially harmful effects of PFAS exposure on human liver health.
机标关键词：associationsubstancesexposurewithadultsamericaninjuryliver
分类号：R114(卫生基础科学)
论文发表日期：2024-11-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：13( 中插9,628-639 )
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