Gold nanorods as biocompatible nano-agents for the enhanced photothermal therapy in skin disorders
Yamei Gao1
Shaohu Huo2
Chao Chen3
Shiyu Du4
Ruiyuan Xia1
Jian Liu1
Dandan Chen1
Ziyue Diao1
Xin Han3
Zhiqiang Yin1
1.Department of Dermatology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China2.Department of Pediatrics,the First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China3.State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,School of Medicine,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210046,China4.College of Engineering and Applied Sciences,State Key Laboratory of Analytical Chemistry for Life Science,Nanjing University,Nanjing,Jiangsu 210008,China
摘要：Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and biocompatible nano-formulations.By optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region,which corresponds to the near-infrared bio-tissue window,GNRs with appropriate modifications may improve the results of photothermal treatment(PTT).In dermatology,potential noninvasive uses of GNRs to enhance wound healing,manage infections,combat cutaneous malignancies,and remodel skin tissues via PTT have attracted research attention in recent years.The review discussed the basic properties of GNRs,such as their shape,size,optical performance,photothermal efficiency,and metabolism.Then,the disadvantages of using these particles in photodynamic therapy are highlighted.Next,biological applications of GNRs-based PTT are explored in detail.Finally,the limitations and future perspectives of this research are addressed,providing a comprehensive perspective on the potential GNRs with PTT.
机标关键词：goldbiocompatibledisordersenhancednano-agentsnanorodsphotothermalskin
分类号：R751.05(皮肤病学)
论文发表日期：2025-01-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：18( 前插1,1-17 )
英文信息