First-episode psychiatric disorder risk from SARS-CoV-2 infection:A clinical analysis with Chinese psychiatric inpatients
Ya Xie1
Zifeng Xu1
Yumin Zhang1
Yisheng Li1
Pengyu Du2
Chun Wang1
1.Clinical Mental Health Center,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China2.Medical School of Nanjing University,Nanjing,Jiangsu 210008,China
摘要：The extensive spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)throughout China in late 2022 has underscored the correlation between this virus and severe psychiatric disorders.However,there remains a lack of reported clinical and pathological features.Accordingly,we retrospectively reviewed the electronic medical records of psychiatric inpatients for seven days from early January 2023.Twenty-one inpatients who developed first-episode psychiatric disorders within two weeks after SARS-CoV-2 infection were recruited,while 24 uninfected first-episode psychiatric inpatients were selected as controls.Comparative analyses of clinical manifestations,routine laboratory tests,and imaging examinations were performed.Our investigation demonstrated a 330%increase in the incidence of first-episode psychiatric inpatients after SARS-CoV-2 infection in 2023,compared with the preceding year without SARS-CoV-2 infections.Most cases exhibited psychiatric symptoms within one week of SARS-CoV-2 infection,which resolved after approximately two weeks,with no residual symptoms after three months.One-way ANOVA demonstrated a significant difference in the highest fever temperature between inpatients with and without psychotic symptoms.Infected inpatients displayed elevated levels of interleukin-4,interleukin-8,and interferon-α,but decreased levels of eosinophils and basophils.These findings suggest that SARS-CoV-2 may contribute to the development of psychiatric disorders,likely mediated by the virus-induced inflammatory response and neuronal dysfunction in the context of psychological distress.
机标关键词：sars-cov-2chineseclinicalanalysisriskwithfromdisorder
分类号：R749(精神病学)
论文发表日期：2025-01-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：12( 中插4,50-60 )
英文信息