Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury
Xuejun Xu1
Kaineng Sun1
Hao Chang1
Chunxiang Shen1
Xiangdong Li2
Yangyue Ni1
Yuxiao Zhu1
Huiquan Wang1
Ruiyan Xiong1
Jon Rob Padde1
Zhipeng Xu1
Lin Chen1
Lu Chen1
Min Hou1
Liyong Pu2
Minjun Ji1
1.Department of Pathogen Biology,National Vaccine Innovation Platform,Jiangsu Province Engineering Research Center of Antibody Drug,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Hepatobiliary Center,Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital,Nanjing,Jiangsu 210029,China
摘要：Ischemia-reperfusion injury(IRI)remains an unavoidable challenge in liver surgery,with macrophages playing a critical role in its pathogenesis.However,the mechanisms by which macrophages regulate the pathogenesis of IRI are not well understood.Through a target-guided screening approach,we identified a small 3 kDa peptide(SjDX5-271)from various schistosome egg-derived peptides that induced M2 macrophage polarization.SjDX5-271 treatment protected mice against liver IRI by promoting M2 macrophage polarization,and this protective effect was abrogated when the macrophages were depleted.Transcriptomic sequencing showed that the TLR signaling pathway was significantly inhibited in macrophages from the SjDX5-271 treatment group.We further identified that SjDX5-271 promoted M2 macrophage polarization by inhibiting the TLR4/MyD88/NF-κB signaling pathway and alleviated hepatic inflammation in liver IRI.Collectively,SjDX5-271 exhibited some promising therapeutic effects in IRI and represented a novel therapeutic approach,potentially applicable to other immune-related diseases.The current study demonstrates the potential of new biologics from the parasite,enhances our understanding of host-parasite interplay,and provides a blueprint for future therapies for immune-related diseases.
机标关键词：ischemianovelalleviatesantiinflammatoryinjuryliverpeptide
分类号：R657.3(外科学各论)
论文发表日期：2025-01-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：16( 中插5,61-75 )
英文信息