Cancer cell membrane-camouflaged biomimetic nanoparticles for enhancing chemo-radiation therapy efficacy in glioma
Chunming Tang1
Yanling Wang1
Min Wu1
Zhiji Wang1
Yupeng Zhou1
Ya Lin1
Yijun Wang2
Huae Xu1
1.Department of Pharmaceutics,School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China2.Department of Pharmacy,the Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210003,China
摘要：Glioblastoma multiforme(GBM)is a highly aggressive and lethal brain tumor with limited treatment options.To improve therapeutic efficacy,we developed a novel multifunctional nanoplatform,GM@P(T/S),comprised of polymeric nanoparticles coated with GBM cell membranes as well as co-loaded with temozolomide(TMZ)and superparamagnetic iron oxide(SPIO)nanoparticles.The successful preparation was confirmed in terms of particle size,morphology,stability,the in vitro drug release,and cellular uptake assays.We demonstrated that GM@P(T/S)exhibited the enhanced homotypic targeting,the prolonged blood circulation,and efficient blood-brain barrier penetration in both in vitro and in vivo studies.The combination of TMZ and SPIO nanoparticles within GM@P(T/S)synergistically improved chemo-radiation therapy,leading to a reduced tumor growth,an increased survival,and minimal systemic toxicity in the orthotopic GBM mouse models.Our findings suggest that GM@P(T/S)holds a great promise as a targeted and efficient therapeutic strategy for GBM.
机标关键词：cancercellbiomimeticcamouflagedchemo-radiationefficacyenhancingglioma
分类号：R943(药剂学)
论文发表日期：2025-01-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：17( 中插7,87-102 )
英文信息