Prophylactic cranial irradiation in small cell lung cancer:A review of evidence
Femi Williams Adeoye
Oncology Department,Southend University Hospital,Mid and South Essex NHS Foundation Trust,Southend-on-Sea,Essex SS0 0RY,UK;The Institute of Cancer Research,London SW7 3RP,UK
摘要：Small cell lung cancer (SCLC),which accounts for about one-sixth of all lung cancer cases,is the most aggressive subtype,with a high propensity for brain involvement[1]. The role of prophylactic cranial irradiation (PCI) in reducing intracranial relapse and improving survival has been a subject of intense debate for decades. Although earlier trials demonstrated its benefits in both early and advanced stages of the disease,the advent of more advanced imaging modalities,the availability of newer systemic anti-cancer therapies,and significant improvement in radiotherapy techniques have made this practice increasingly controversial within the oncology community. This article reviews the existing evidence in light of these recent developments and explores perspectives on the future of PCI in SCLC.
机标关键词：reviewsmallcancercellcranialevidenceirradiationlung
分类号：R734.2(呼吸系肿瘤)
论文发表日期：2025-03-30
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：5( 中插1,128-131 )