A healthy lifestyle pattern and mortality risk in patients with type 2 diabetes mellitus:A prospective cohort study in China
Hao Yu1
Xinyi Liu2
Xueni Cheng2
Xikang Fan1
Yuefan Shen2
Ke Liu3
Yanan Wan1
Jian Su1
Yu Qin1
Zhongming Sun4
Yan Lu5
Shujun Gu6
Chong Shen2
Dong Hang7
Jinyi Zhou1
1.Department of Non-communicable Chronic Disease Control,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing,Jiangsu 210009,China2.Department of Epidemiology,Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China3.Department of Epidemiology and Health Statistics,School of Public Health,Southeast University,Nanjing,Jiangsu 210009,China4.Department of Chronic Disease Prevention and Control,Huai'an City Center for Disease Control and Prevention,Huai'an,Jiangsu 223001,China5.Department of Chronic Disease Prevention and Control,Suzhou City Center for Disease Control and Prevention,Suzhou,Jiangsu 215003,China6.Department of Chronic Disease Prevention and Control,Changshu City Center for Disease Control and Prevention,Changshu,Jiangsu 215500,China7.Department of Epidemiology,Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Changzhou Medical Center,Nanjing Medical University,Changzhou,Jiangsu 213000,China
摘要：This study aimed to evaluate the association of a healthy lifestyle pattern with mortality risk among patients with type 2 diabetes mellitus(T2DM).Data were derived from a prospective cohort study enrolling 13 776 Chinese patients with T2DM.A healthy lifestyle pattern was constructed based on six lifestyle factors,including smoking status,alcohol consumption,dietary habits,physical activity,sedentary time,and sleep duration.Multivariate Cox proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for all-cause and cause-specific mortality.During a median follow-up of 9.78 years,2 497 deaths were recorded.Compared with T2DM patients with a lifestyle pattern scoring 0-2,those scoring 5-6 had a 40%lower risk for all-cause mortality(HR=0.60,95%CI:0.52-0.69),a 33%lower risk for cardiovascular disease mortality(HR=0.67,95%CI:0.52-0.86),and a 25%lower risk for cancer mortality(HR=0.75,95%CI:0.58-0.97).Additionally,we found that the association between the lifestyle pattern and all-cause mortality risk was stronger in females than in males(P for interaction<0.05).In conclusion,adherence to a healthy lifestyle pattern is associated with a decreased risk of all-cause,cardiovascular disease,and cancer mortality.These findings have important implications for reducing premature mortality among patients with T2DM.
机标关键词：studyriskchinawithcohortdiabeteshealthylifestyle
分类号：R587.1(内分泌腺疾病及代谢病)
论文发表日期：2025-11-30
在线出版日期：2026-01-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 639-647,中插29-中插35 )
英文信息