Dual function of fungi-derived cytokines in inflammatory bowel diseases:protection or inflammation
Niusha Sharifinejad1
Elaheh Mahmoudi2
1.Non-Communicable Diseases Research Center,Alborz University of Medical Sciences,Karaj,Iran2.Department of Mycology,School of Medicine,Alborz University of Medical Sciences,Karaj,Iran
摘要：Inflammatory bowel disease(IBD)is an immune-mediated inflammatory condition involving both the innate and adaptive immune systems.Recently,the role of intestinal fungal flora and their downstream immune pathways has been highlighted in the pathogen-esis of IBD.Cytokines as primary immune mediators require a delicate balance for maintaining intestinal homeostasis.Although most cytokines have a predictable role in either amplifying or attenuating inflammation in IBD,a few cytokines have shown a dual function in the inflammatory state of the intestine.Some of these dual-faced cytokines are also involved in mucosal anti-microbial defense pathways,particularly against intestinal fungal residents.Here,we reviewed the role of these cytokines in IBD pathogenesis to achieve a better understanding of the fungal interactions in the development of IBD.
机标关键词：protectionfunctiondualbowelcytokinesdiseasesfungi-derivedinflammation
论文发表日期：2024-04-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：9( 108-116 )
英文信息