Amino acid-based enteral nutrition is effective for pediatric Crohn's disease:a multicenter prospective study
Qingfan Yang1
Ting Zhang2
Na Diao1
Kang Chao1
Huijun Shu3
Jie Wu4
Dexiu Guan4
Li Wang5
Xiwei Xu4
Zhenghong Li6
Xiang Gao1
1.Department of Gastroenterology,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,P.R.China;Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,P.R.China;Biomedical Innovation Center,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,P.R.China2.Department of Gastroenterology,Hepatology and Nutrition,Shanghai Children's Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,P.R.China3.Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,P.R.China4.Department of Gastroenterology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing,P.R.China5.Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing,P.R.China6.Department of Pediatrics,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing,P.R.China
摘要：Background:Exclusive enteral nutrition(EEN)therapy effectively induces remission in pediatric Crohn's disease(CD).However,this may depend on the type of enteral formula used.Moreover,data on the efficacy of amino acid-based EEN are limited.Thus,we aimed to prospectively evaluate the efficacy of amino acid-based formulas for EEN in pediatric patients with active CD.
Methods:Patients with active CD aged between 6 and 17 years were recruited into this prospective study from four hospitals in China between March 2019 and December 2021.Patients received EEN for 8 weeks.Inflammatory and nutrition-associated indices were evaluated at 0,4,and 8 weeks after treatment.Paired t-tests and Wilcoxon signed-rank tests were used to compare continuous and categorical variables before and after intervention,respectively.
Results:Twenty-four patients were included in the analysis.After an 8-week intervention period,the CD activity index significantly decreased(26.3±12.2 vs 7.1±8.3,P<0.001).Most patients(66.7%)achieved complete clinical remission.Among the 22 patients who had ulcers and erosions diagnosed endoscopically at baseline,10(45.5%)achieved complete mucosal healing.The degree of thicken-ing of the intestinal wall was significantly reduced after EEN intervention,with a transmural healing rate of 42.9%.Furthermore,the serum inflammatory markers decreased and there was a significant improvement in the nutrition-related indices(P<0.05).There were no severe adverse effects.
Conclusions:Amino acid-based EEN is effective and safe for treating pediatric-onset CD.Studies with larger sample sizes and mech-anistic and follow-up studies are required to further validate these findings.
机标关键词：nutritioncrohnaminostudyacid-baseddiseaseeffectiveenteral
论文发表日期：2024-04-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：8( 157-164 )
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