Hypoxia,hypoxia-inducible factors and inflammatory bowel diseases
Fei Hou1
Xixi Bian2
Dehuai Jing3
Huikuan Gao4
Fengqin Zhu3
1.Department of Critical Liver Diseases,Liver Research Center,Beijing Friendship Hospital,Capital Medical University,Beijing,P.R.China2.Department of Gastroenterology,Affiliated Hospital of Jining Medical University,Jining Medical University,Jining,Shandong,P.R.China;Clinical Medical College of Jining Medical University,Department of Clinical Medicine,Jining Medical University,Jining,Shandong,P.R.China3.Department of Gastroenterology,Affiliated Hospital of Jining Medical University,Jining Medical University,Jining,Shandong,P.R.China4.Department of Cardiology,Beijing Friendship Hospital,Capital Medical University,Beijing,P.R.China
摘要：Adequate oxygen supply is essential for maintaining the body's normal physiological function.In chronic inflammatory conditions such as inflammatory bowel disease(IBD),insufficient oxygen reaching the intestine triggers the regulatory system in response to environmental changes.However,the pathogenesis of IBD is still under investigation.Recent research has highlighted the significant role of hypoxia in IBD,particularly the involvement of hypoxia-inducible factors(HIF)and their regulatory mechanisms,making them promising therapeutic targets for IBD.This review will delve into the role of hypoxia,HIF,and the associated hypoxia-inflammatory microenvironment in the context of IBD.Potential interventions for addressing these challenging gastrointestinal inflammatory diseases will also be discussed within this framework.
机标关键词：hypoxiaboweldiseasesfactorsinducibleinflammatory
论文发表日期：2024-06-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：7( 202-208 )
英文信息