Current advances and future directions in combined hepatocellular and cholangiocarcinoma
Yu-Zhu Zhang1
Yu-Chen Liu2
Tong Su1
Jiang-Nan Shi3
Yi Huang3
Bo Liang4
1.Department of General Surgery,The Second Affiliated Hospital of Nanchang University,Jiangxi,Nanchang,Jiangxi,P.R.China;The Second Clinical Medical College of Nanchang University,The Second Affiliated Hospital of Nanchang University,Jiangxi,Nanchang,Jiangxi,P.R.China2.Department of General Surgery,The Second Affiliated Hospital of Nanchang University,Jiangxi,Nanchang,Jiangxi,P.R.China;Queen Mary School,Jiangxi Medical College of Nanchang University,Nanchang,Jiangxi,P.R.China3.The Second Clinical Medical College of Nanchang University,The Second Affiliated Hospital of Nanchang University,Jiangxi,Nanchang,Jiangxi,P.R.China4.Department of General Surgery,The Second Affiliated Hospital of Nanchang University,Jiangxi,Nanchang,Jiangxi,P.R.China
摘要：The low incidence of combined hepatocellular cholangiocarcinoma(cHCC-CCA)is an important factor limiting research progression.Our study extensively included nearly three decades of relevant literature and assembled the most comprehensive database com-prising 5,742 patients with cHCC-CCA.We summarized the characteristics,tumor markers,and clinical features of these patients.Additionally,we present the evolution of cHCC-CCA classification and explain the underlying rationale for these classification stand-ards.We reviewed cHCC-CCA diagnostic advances using imaging features,tumor markers,and postoperative pathology,as well as treatment options such as surgical,adjuvant,and immune-targeted therapies.In addition,recent advances in more effective chemo-therapeutic regimens and immune-targeted therapies were explored.Furthermore,we described the molecular mutation features and potential specific markers of cHCC-CCA.The prognostic value of Nestin has been proven,and we speculate that Nestin will also play a role in classification and diagnosis.However,further research is needed.Moreover,we believe that the possibility of using machine learning liquid biopsy for preoperative diagnosis and establishing a scoring system are directions for future research.
机标关键词：currentfuturecholocarolanadvancescarcinomacombined
论文发表日期：2024-08-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：12( 293-304 )
英文信息