Prediction of immunocyte infiltration and prognosis in postoperative hepatitis B virus-related hepatocellular carcinoma patients using magnetic resonance imaging
Chenyu Song1
Mengqi Huang2
Xiaoqi Zhou1
Yuying Chen1
Zhoulei Li1
Mimi Tang1
Meicheng Chen1
Zhenpeng Peng1
Shiting Feng1
1.Department of Radiology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China2.Department of Radiology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China;Department of Radiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,P.R.China
摘要：Background:The immune microenvironment(IME)is closely associated with prognosis and therapeutic response of hepatitis B virus-related hepatocellular carcinoma(HBV-HCC).Multi-parametric magnetic resonance imaging(MRI)enables non-invasive as-sessment of IME and predicts prognosis in HBV-HCC.We aimed to construct an MRI prediction model of the immunocyte-infiltration subtypes and explore its prognostic significance.
Methods:HBV-HCC patients at the First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)with radical surgery(be-tween 1 October and 30 December 2021)were prospectively enrolled.Patients with pathologically proven HCC(between 1 December 2013 and 30 October 2019)were retrospectively enrolled.Pearson correlation analysis was used to examine the relationship between the immunocyte-infiltration counts and MRI parameters.An MRI prediction model of immunocyte-infiltration subtypes was con-structed in prospective cohort.Kaplan-Meier survival analysis was used to analyse its prognostic significance in the retrospec-tive cohort.
Results:Twenty-four patients were prospectively enrolled to construct the MRI prediction model.Eighty-nine patients were retro-spectively enrolled to determine its prognostic significance.MRI parameters(relative enhancement,ratio of the apparent diffusion coefficient value of tumoral region to peritumoral region[rADC],T1 value)correlated significantly with the immunocyte-infiltration counts(leukocytes,T help cells,PD1+Tc cells,B lymphocytes).rADC differed significantly between high and low immunocyte-infiltration groups(1.47±0.36 vs 1.09±0.25,P=0.009).The area under the curve of the MRI model was 0.787(95%confidence interval 0.587-0.987).Based on the MRI model,the recurrence-free time was longer in the high immunocyte-infiltration group than in the low immunocyte-infiltration group(P=0.026).
Conclusions:MRI is a non-invasive method for assessing the IME and immunocyte-infiltration subtypes,and predicting prognosis in post-operative HBV-HCC patients.
机标关键词：predictionprognosisimagingcarcinomahepatitishepatocellularimmunocyteinfiltration
论文发表日期：2024-08-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：10( 333-342 )
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