Gastrointestinal microbiota-directed nutritional and therapeutic interventions for inflammatory bowel disease:opportunities and challenges
Devendra Paudel1
Divek V.T.Nair1
Grace Joseph1
Rita Castro2
Amit K.Tiwari3
Vishal Singh1
1.Department of Nutritional Sciences,The Pennsylvania State University,University Park,PA,USA2.Department of Nutritional Sciences,The Pennsylvania State University,University Park,PA,USA;Department of Pharmaceutical Sciences and Medicines,Faculty of Pharmacy,Universidade de Lisboa,Lisboa,Portugal3.College of Pharmacy,University of Arkansas for Medical Sciences,Little Rock,AR,USA
摘要：Evidence-based research has confirmed the role of gastrointestinal microbiota in regulating intestinal inflammation.These data have generated interest in developing microbiota-based therapies for the prevention and management of inflammatory bowel dis-ease(IBD).Despite in-depth understanding of the etiology of IBD,it currently lacks a cure and requires ongoing management.Accumulating data suggest that an aberrant gastrointestinal microbiome,often referred to as dysbiosis,is a significant environmen-tal instigator of IBD.Novel microbiome-targeted interventions including prebiotics,probiotics,fecal microbiota transplant,and small molecule microbiome modulators are being evaluated as therapeutic interventions to attenuate intestinal inflammation by restoring a healthy microbiota composition and function.In this review,the effectiveness and challenges of microbiome-centered interven-tions that have the potential to alleviate intestinal inflammation and improve clinical outcomes of IBD are explored.
机标关键词：astrogastbowelchallengesdirecteddiseaseinflammatoryinterventions
论文发表日期：2024-10-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：9( 409-417 )
英文信息