Research progress on the role of mitochondria in the process of hepatic ischemia-reperfusion injury
Yujie Zhou1
Tao Qiu1
Tianyu Wang1
Bo Yu1
Kang Xia1
Jiayu Guo1
Yiting Liu1
Xiaoxiong Ma2
Long Zhang2
Jilin Zou2
Zhongbao Chen2
Jiangqiao Zhou1
1.Department of Organ Transplantation,Renmin Hospital of Wuhan University,Wuhan,Hubei,P.R.China;Department of Urology,Renmin Hospital of Wuhan University,Wuhan,Hubei,P.R.China2.Department of Organ Transplantation,Renmin Hospital of Wuhan University,Wuhan,Hubei,P.R.China
摘要：During liver ischemia-reperfusion injury,existing mechanisms involved oxidative stress,calcium overload,and the activation of in-flammatory responses involve mitochondrial injury.Mitochondrial autophagy,a process that maintains the normal physiological ac-tivity of mitochondria,promotes cellular metabolism,improves cellular function,and facilitates organelle renewal.Mitochondrial autophagy is involved in oxidative stress and apoptosis,of which the PINK1-Parkin pathway is a major regulatory pathway,and the deletion of PINK1 and Parkin increases mitochondrial damage,reactive oxygen species production,and inflammatory response,play-ing an important role in mitochondrial quality regulation.In addition,proper mitochondrial permeability translational cycle regula-tion can help maintain mitochondrial stability and mitigate hepatocyte death during ischemia-reperfusion injury.This mechanism is also closely related to oxidative stress,calcium overload,and the aforementioned autophagy pathway,all of which leads to the augmentation of the mitochondrial membrane permeability transition pore opening and cause apoptosis.Moreover,the release of mitochondrial DNA(mtDNA)due to oxidative stress further aggravates mitochondrial function impairment.Mitochondrial fission and fusion are non-negligible processes required to maintain the dynamic renewal of mitochondria and are essential to the dynamic stability of these organelles.The Bcl-2 protein family also plays an important regulatory role in the mitochondrial apoptosis signaling pathway.A series of complex mechanisms work together to cause hepatic ischemia-reperfusion injury(HIRI).This article reviews the role of mitochondria in HIRI,hoping to provide new therapeutic clues for alleviating HIRI in clinical practice.
机标关键词：ischemiaresearchprocessrolehepaticinjurymitochondriaprogress
论文发表日期：2024-10-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：11( 418-428 )
英文信息