Active role of the immune system in metabolic dysfunction-associated steatotic liver disease
Taizo Mori
Sachiyo Yoshio
Eiji Kakazu
Tatsuya Kanto
Department of Liver Diseases,The Research Center for Hepatitis and Immunology,National Center for Global Health and Medicine,Chiba,Japan
摘要：Non-alcoholic fatty liver disease,recently renamed metabolic dysfunction-associated steatotic liver disease(MASLD),is a complex multifactorial disease that progresses from steatohepatitis(MASH)to liver cirrhosis and liver cancer.Recent research has revealed that crosstalk between innate immune cells and hepatic parenchymal and non-parenchymal cells is involved in the pathogenesis of liver disease in MASLD/MASH.Of particular importance,novel inflammatory mechanisms,including macrophage diversity,neutro-phil NETosis,B-cell biology,auto-reactive T cells,unconventional T cells,and dendritic cell-T cell interactions,are considered key drivers for disease progression.These mechanisms and factors are potential targets for the therapeutic intervention of MASLD/MASH.In this review,we focus on recent discoveries related to liver inflammation and discuss the role of innate immune cell subsets in MASLD/MASH.
机标关键词：metabolicactiverolesystemassociateddiseasedysfunctionimmune
论文发表日期：2024-12-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：11( 575-585 )
英文信息