Advances in the management of alcohol-associated liver disease
Ahmad Anouti
Thomas A.Kerr
Mack C.Mitchell
Thomas G.Cotter
Division of Digestive and Liver Diseases,UT Southwestern Medical Center,Dallas,TX,USA
摘要：Alcohol-associated liver disease(ALD)is a significant global health challenge,encompassing a spectrum from steatotic liver disease to cirrhosis and alcohol-associated hepatitis,and contributed to 25%of global cirrhosis deaths in 2019.The identification of both modifiable(e.g.heavy drinking,metabolic syndromes)and non-modifiable risk factors(e.g.genetic predispositions)is crucial for effective disease management.Alcohol use assessment and treatment,by using both behavioral therapy and pharmacotherapeutic modalities,nutrition support,and optimization of liver disease modifiers,form the cornerstone of management.Advances in medical therapies,such as fecal microbiota transplantation and novel agents such as IL-22,are being explored for their therapeutic potential.A unifying theme in ALD care is the need for a personalized approach to management,accounting for the spectrum of the disease and individual patient character-istics,to tailor interventions effectively.Finally,it is essential to address the challenges to effective ALD treatment,including socioeco-nomic,logistical,and stigma-related barriers,to improve patient outcomes.This review discusses the current knowledge on ALD,including epidemiology,pathophysiology,risk factors,and management strategies,highlighting the critical role of integrated care models.
机标关键词：managementadvancesalcoholassociateddiseaseliver
论文发表日期：2024-12-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：16( 586-601 )
英文信息