Association between low-normal thyroid function and advanced liver fibrosis in metabolic dysfunction-associated fatty liver disease patients:a retrospective cohort study
Zixuan Li1
Xiaoying Wu2
Zebin Chen3
Xiuqing Wei2
Weiqing Chen1
1.Department of Epidemiology,School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China2.Department of Gastroenterology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,P.R.China3.Center of Hepato-Pancreatico-Biliary Surgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China
摘要：Background:Recent studies have found that thyroid function may be associated with the occurrence and development of advanced liver fibrosis in patients with metabolic dysfunction-associated fatty liver disease(MAFLD).However,the majority of such research has consisted of cross-sectional studies.This retrospective cohort study aimed to investigate the effect of low-normal thyroid function on advanced liver fibrosis in MAFLD patients over a 5-year period.
Methods:This retrospective cohort study enrolled 825 outpatients and inpatients with MAFLD who attended the Third Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between January 2011 and December 2018.Based on plasma thyroid hormone and thyroid-stimulating hormone levels,these patients were divided into two groups,namely a low-normal thyroid function group and a strict-normal thyroid function group.The fibrosis-4 score was used to assess advanced liver fibrosis.A chi-square test was conducted to compare the occurrence of advanced fibrosis between the groups.
Results:Among the 825 MAFLD patients,117 and 708 were defined as having low-normal thyroid function and strict-normal thyroid function,respectively.Follow-up data were available for 767 patients(93.0%)during a 5-year period.Eight(7.5%)MAFLD patients with low-normal thyroid function and 26(3.9%)with strict-normal thyroid function developed advanced liver fibrosis and the cumulative incidence was not significantly different(P=0.163).Stratification analysis showed that the lean MAFLD patients(body mass index≤23 kg/m2)with low-normal thyroid function had a higher risk of advanced liver fibrosis than the lean MAFLD patients with strict-normal thyroid function(P<0.05).
Conclusion:Low-normal thyroid function is associated with advanced liver fibrosis among lean MAFLD patients.
机标关键词：associationmetabolicfibrosisadvancedbetweenstudyassociatedcohort
论文发表日期：2024-12-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：6( 610-615 )
英文信息