Celiac artery mesenteric fat measurement with endosonography(CAMEUS)reliably correlates with obesity and related comorbidities
Fateh Bazerbachi1
Serge Baroud2
Michael J.Levy3
Daniel B.Maselli3
Eric J.Vargas3
Aliana Bofill-Garcia3
Ryan J.Law3
Vinay Chandrasekhara3
Andrew C.Storm3
Ferga C.Gleeson3
Elizabeth Rajan3
Prasad G.Iyer3
Kymberly D.Watt3
Barham K.Abu Dayyeh3
1.CentraCare,Interventional Endoscopy Program,St Cloud Hospital,St.Cloud,MN,USA;Division of Gastroenterology,Hepatology and Nutrition,University of Minnesota,Minneapolis,MN,USA2.Department of Internal Medicine,MetroHealth Medical Center and Case Western Reserve University,Cleveland,OH,USA3.Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA
摘要：Background:Visceral fat represents a metabolically active entity linked to adverse metabolic sequelae of obesity.We aimed to determine if celiac artery mesenteric fat thickness can be reliably measured during endoscopic ultrasound(EUS),and if these meas-urements correlate with metabolic disease burden.
Methods:This was a retrospective analysis of patients who underwent celiac artery mesenteric fat measurement with endosonogra-phy(CAMEUS)measurement at a tertiary referral center,and a validation prospective trial of patients with obesity and nonalcoholic steatohepatitis who received paired EUS exams with CAMEUS measurement before and after six months of treatment with an intra-gastric balloon.
Results:CAMEUS was measured in 154 patients[56.5%females,mean age 56.5±18.0 years,body mass index(BMI)29.8±8.0 kg/m2]and was estimated at 14.7±6.5 mm.CAMEUS better correlated with the presence of non-alcoholic fatty liver disease(NAFLD)(R2=0.248,P<0.001)than BMI(R2=0.153,P<0.001),and significantly correlated with metabolic parameters and diseases.After six months of intragastric balloon placement,the prospective cohort experienced 11.7%total body weight loss,1.3 points improvement in hemoglo-bin A1c(P=0.001),and a 29.4%average decrease in CAMEUS(-6.4±5.2 mm,P<0.001).CAMEUS correlated with improvements in weight(R2=0.368),aspartate aminotransferase to platelet ratio index(R2=0.138),and NAFLD activity score(R2=0.156)(all P<0.05).
Conclusions:CAMEUS is a novel measure that is significantly correlated with critical metabolic indices and can be easily captured during routine EUS to risk-stratify susceptible patients.This station could allow for EUS access to sampling and therapeutics of this metabolic region.
机标关键词：measurementwitharterycameusceliaccomorbiditiescorrelatesendosonography
论文发表日期：2024-12-30
在线出版日期：2026-07-17（本平台首次上网日期，不代表文献的发表时间）
页数：7( 616-622 )
英文信息