DOI: 10.1515/mr-2021-0003
Resident stem cells in the heart
Hui Gong1
Ting Wang1
Qingbo Xu2
1.Department of Cardiology,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,China2.Department of Cardiology,The First Affiliated Hospital,Zhejiang University School of Medicine,79 Qingchun Road,Hangzhou 310003,Zhejiang,China
摘要：Cardiovascular disease is the leading cause of mobility and morality worldwide,in which the ischemic heart disease is the most common type of the diseases.During last decade,a major progress in the study of the pathogenesis of heart disease has been achieved.For example,the discovery of adult stem/progenitor cells in the heart and vessel tissues may play a role in tissue regeneration.However,the issue of 31 retractions for car-diac stem cell work has caused a"storm of trust"in the heart stem cell field,in which both founders and scientists have become cautious and conservative in stem cell research of the heart.Despite that the existence of adult cardiac stem cells has been denied,recent studies confirmed that there are many other resident stem/pro-genitor cells in adult heart.Although these cells cannot differentiate into cardiomyocytes,the role they played in heart repair after injury should not be ignored.The purpose of this short article is to briefly review the current research progress in resident stem/progenitor cells in the heart,to discuss how they function during cardiac repair and to point out unanswered questions in the research field.
机标关键词：stemcellsheartresident
论文发表日期：2021-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 10-13 )
英文信息